Histotechnologist II

Company: Exact Sciences
Location: Phoenix
Posted on: January 13, 2026

Job Description:

Help us change lives At Exact Sciences, we’re helping change how the world prevents, detects and guides treatment for cancer. We give patients and clinicians the clarity needed to make confident decisions when they matter most. Join our team to find a purpose-driven career, an inclusive culture, and robust benefits to support your life while you’re working to help others. Position Overview The Histotechnologist II will perform a variety of histology laboratory procedures used to produce tissue slides and support the general laboratory duties expected to be performed in a CLIA/CAP-certified histopathology laboratory. The Histotechnologist II shall adhere to all safety, quality controls, and procedures, and learn and perform all functions of histology, pathology, and molecular aspects needed in the laboratory. Essential Duties Include, but are not limited to, the following: - Label documentation of formalin-fixed paraffin-embedded (FFPE) blocks, slides, and microcentrifuge tubes by following standard operating procedures (SOPs). - Routine sectioning, fixation, and processing procedures related to hematoxylin and eosin (H&E) staining/slide production for fresh frozen (FF) and FFPE samples according to SOPs. - Prepare and perform processing procedures for DNA and RNA analyze extraction according to SOPs. - Label accessioned samples/sample containers and test requisition form using the laboratory labeling system with assigned number specific to the patient case from laboratory information system (LIS) accessioning. - Prepare and perform all aspects related to the routine processing of FF tissue samples, to include preparation for tumor estimate procedure, according to SOPs. - Accession and enter data of received patient samples and specific test request into LIS according to SOPs. - File and store all slides and FFPE tissue blocks. - Assist with the initial quality review of incoming specimens. - Maintain all histology equipment and corresponding documentation; including, but not limited to, quality control worksheets, preventive maintenance records, and day-to-day maintenance. - Enter data into the histology portion of the information management system (IMS). - Perform routine and/or non-routine histology procedures, and regularly review work to ensure work is carried out in accordance with established policies and procedures. - Perform microdissection of unstained slides in accordance with markings of stained slides provided. - Prepare reagents, solutions, and controls. - Perform and document equipment maintenance and calibration. - Assist in sample returns, as needed. - Interact with pathologists and laboratory staff, in accordance with SOPs, to ensure specimens are processed in a timely manner with high quality. - Provide materials and reagent receipt and management in accordance with SOPs. - Provide technical assistance to other staff, as needed. - Assist in training team members, as needed. - Perform H&E staining. - Monitor and process the histology queue for various tasks that need to be performed and perform these tasks with minimal supervision. - Ability to prioritize and drive to results with a high emphasis on quality. - Ability to work independently as well as part of a team. - Ability to multi-task and rapidly switch directions to accommodate changes in study designs. - Display high attention to detail. - Strong interpersonal and written and verbal communication skills. - Uphold company mission and values through accountability, innovation, integrity, quality, and teamwork. - Support and comply with the company’s Quality Management System policies and procedures. - Maintain regular and reliable attendance. - Ability to act with an inclusion mindset and model these behaviors for the organization. - Ability to work designated schedule. - Ability to work nights and/or weekends, as needed. - Ability to work overtime, as needed. - Ability to use various types of laboratory equipment; including microscopes, microtomes, blades, strainers, and pipettes for extended periods of time. - May perform repetitious actions using lab tools. - Ability to use near vision to view samples at close range. - Ability to spend considerable periods of time concentrating, reading, or analyzing data, or applying scientific rules. - May be exposed to hazardous materials, tissue specimens, and instruments with moving parts, lasers, heating and freezing elements, and high-speed centrifugation. - Ability to grasp with both hands; pinch with thumb and forefinger; turn with hand/arm; reach above shoulder height. - Ability to comply with any applicable personal protective equipment requirements. Minimum Qualifications - Successful completion of a NAACLS accredited Histotechnician program, 3 years of laboratory experience (one year of experience can be counted from the program completion). - Or High School diploma, 5 years of laboratory experience. - Or Associate Degree in a scientific field, 3 years of laboratory experience. - Or Bachelor Degree in a scientific field, 1 years of laboratory experience. - Basic computer skills to include internet navigation and email usage. - Demonstrated ability to perform the essential duties of the position with or without accommodation. - Authorization to work in the United States without sponsorship. Preferred Qualifications - Possession of active ASCP Board of Certification, such as HT ASCP, HLT ASCP. LI-SM1 Salary Range: $56,000.00 - $100,000.00 The annual base salary shown is for this position located in US - AZ - Phoenix on a full-time basis. In addition, this position is bonus eligible. Exact Sciences is proud to offer an employee experience that includes paid time off (including days for vacation, holidays, volunteering, and personal time), paid leave for parents and caregivers, a retirement savings plan, wellness support, and health benefits including medical, prescription drug, dental, and vision coverage. Learn more about our benefits. Our success relies on the experiences and perspectives of a diverse team, and Exact Sciences fosters a culture where all employees can develop personally and professionally with a sense of respect and belonging. If you require an accommodation, please contact us here. Not ready to apply? Join our Talent Community to stay updated on the latest news and opportunities at Exact Sciences. We are an equal employment opportunity employer. All qualified applicants will receive consideration for employment without regard to disability, protected veteran status, and any other status protected by applicable local, state, or federal law. To view the Right to Work, E-Verify Employer, and Pay Transparency notices and Federal, Federal Contractor, and State employment law posters, visit our compliance hub. The documents summarize important details of the law and provide key points that you have a right to know.

Keywords: Exact Sciences, Surprise , Histotechnologist II, Science, Research & Development , Phoenix, Arizona